Serving as an oncogene or tumor suppressor gene, in bladder cancer, ciRS-7 is found to suppress bladder cancer growth by elevating p21 [6]; hypoxia elevates circELP3 to promote bladder cancer progression and drug resistance [7]; circular RNA CEP128 promotes bladder cancer cell propagation and migration via regulating MAPK signaling [8]; and circHIPK3 decreases lung metastasis through suppressing heparanase expression [9]. This evidence concerns the gene HPSE and urinary bladder cancer.