Such as, ciRS-7 enables to suppress cancer growth by elevating p21 [6]; circELP3 promotes progression and drug resistance of bladder cancer [7]; circHIPK3 decreases lung metastasis through suppressing heparanase expression [9]; circular RNA CEP128 promotes bladder cancer cell propagation and migration via MAPK signaling [8]. The gene discussed is HPSE; the disease is urinary bladder cancer.