Additionally, recent data from the De-ESCALaTE and RTOG 1016 trials comparing concomitant cetuximab with cisplatin during radiotherapy in HPV-positive oropharyngeal carcinoma demonstrated inferiority of the EGFR inhibitor in terms of OS and PFS, and it remains to be demonstrated if these results also hold true for other HNSCC subtypes [34, 35]. Here, EGFR is linked to head and neck squamous cell carcinoma.