Knockdown of SOX2OT in lung cancer decreased EZH2 expression and inhibited cell proliferation by inducing G2/M arrest [32], while knockdown of SOX2OT decreased SOX2 and OCT4 expression and inhibited stem cell pluripotency and tumourigenesis in oesophageal squamous cell carcinoma [43]. The gene discussed is EZH2; the disease is lung cancer.