Knockdown of SOX2OT in lung cancer decreased EZH2 expression and inhibited cell proliferation by inducing G2/M arrest [32], while knockdown of SOX2OT decreased SOX2 and OCT4 expression and inhibited stem cell pluripotency and tumourigenesis in oesophageal squamous cell carcinoma [43]. This evidence concerns the gene POU5F1 and lung cancer.