The authors of a study including 13 obese and non-obese adolescents found 55 different miRNAs (including miRNA 148b, miRNA 4269, miRNA 23b, miRNA 4429) in obese individuals compared to those with a BMI < 25 kg/m2, and they were associated with an increase in insulin resistance, which is responsible for target organ damage in obesity [39]. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.