ANGPTL4 and neoplasm: To identify key components of these candidate genes, those fit with significantly and differentially expressed between tumor and normal samples, selected as an important feature by lasso, and significant in both univariate and multivariate coxph tests were candidate genes, restricting down to 4 genes (MAP3K8, CCL20, VEGFC, and ANGPTL4) with P-values less than 0.01 as potential parameters for use in our model (Additional file 4: Table S3).