In addition, we separately screened 16 PD genes on the panel (SNCA, LRRK2, PRKN, PINK1, PARK7, ATP13A2, EIF4G1, GIGYF2, PLA2G6, FBXO7, VPS35, MAPT, HTRA2, SPG11, GRN and DCTN1) for all sequence variants, and these results are shown in Additional file 8: Table S5). This evidence concerns the gene SPG11 and Parkinson disease.