Among these 53 genes, expression of 11 genes (Timp2, Ezh1, Foxo4, Nomo1, Pten, Tpp1, Plagl2, Chfr, Fbxo3, Lats2, and Cbl) that are predicted targets of miR-214 were further analyzed because of their known involvement in cancer (Figure 5C and Figure S4A). The gene discussed is FBXO3; the disease is cancer.