This is important as the two putative CSC subpopulations identified are both OCT4+/SOX2+/KLF4+/c-MYC+ and therefore may indicate an interaction between the TNs and the PTS in promoting tumor growth [60], although these two subpopulations are distinct from one another, each playing a role in tumorigenesis. The gene discussed is KLF4; the disease is neoplasm.