Accumulating data demonstrate that in advanced tumor stages two inhibitory receptors structurally related to DNAM-1 are up-regulated on NK and cytotoxic T cells: T-cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) and T cell-activated increased late expression (Tactile), also known as CD96 [68]. The gene discussed is CD96; the disease is neoplasm.