Thus, it is not surprising that the deregulation of NRF2 expression or activity has been found in many diseases in which oxidative stress represents a typical pathologic feature, including cancer [12], multiple sclerosis (MS) [9], Alzheimer’s disease (AD) [13], Parkinson’s disease (PD) [13], and amyotrophic lateral sclerosis (ASL) [14]. Here, NFE2L2 is linked to Parkinson disease.