NLRP3 and age-related macular degeneration: Mice models of AMD including Ccl2/Cx3cr1 double knockout [117], chimeric Cfh transgenic [118], and Ceruloplasmin/Hephaestin double knockout (Cpc−/−Heph−/−) [132] similarly showed NLRP3 expression with age, while NLRP3 knockout in the VEGF-Ahyper mouse resulted in a reduced number of choroidal neovascularization (CNV) lesions [133].