α-Mangostin (10) reduced the levels of proinflammatory cytokine IL-6, COX-2, and 18 kDa translocator protein (TSPO) in the brain from LPS-induced neuroinflammation in C57BL/6J mice, which was considered as an adjuvant treatment in preclinical models of AD, PD, and multiple sclerosis [58]. This evidence concerns the gene TSPO and multiple sclerosis.