For example, the screening of 1250 mutant Drosophila lines allowed the identification of 30 specific modifiers of tau-induced neurodegeneration, among which were several components of the actin cytoskeleton, such as Tpm [163] and myosin VI, which colocalize with tau protein accumulated in the neurons of AD patients and of tauopathy animal models [164]. Here, MAPT is linked to Alzheimer disease.