The conclusions drawn from the analysis of ischemia-triggered Alzheimer’s disease-related tau protein and its gene in the brain, which are part of the cause of neuronal death by generation of neurofibrillary tangle-like and/or neurofibrillary tangles, are crucial for the improvement of therapy of irreversible post-ischemic neurodegeneration. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.