There is no apparent Drosophila homolog of TREM2. However, a recent study using Drosophila AD models shows that glial expression of human TREM2 or human tyrosine kinase binding protein (TYROBP), the intracellular adaptor of TREM2, did not affect AD-like phenotypes of Aβ42-expressing flies, while glial expression of TREM2/TYROBP modifies molecular signatures induced by neuronal expression of Aβ42 [227]. This evidence concerns the gene TREM2 and Alzheimer disease.