In human cell models, more than 40 tau phosphorylation sites are associated with AD [91,92,93,94]: Serine (Ser) 262 and Ser356 are phosphorylated by MARK [89,90], and Threonine (Thr) 231, Ser199, Ser202, Ser235, Ser396, and Ser404 by GSK3β [95,96,97,98]. The gene discussed is MAPT; the disease is Alzheimer disease.