In particular, we observed enhanced tumor angiogenesis, increasing pro-angiogenic and lymphangiogenic factors, such as VEGF, MMP-9, CCL2, and VEGFD, and a significant recruitment of tumor-associated macrophages in lymphomas of Ibtk+/-Eμ-myc compared to Ibtk+/+Eμ-myc mice. The gene discussed is IBTK; the disease is lymphoma.