This inconsistent finding could be an artifact of our relatively small sample size, or might be the result of negative correlations among the predictors, but nonetheless suggests that controlling for BMI may be important in future studies examining the relationship between smoking, GPR15+ Th levels, and inflammatory disease, particularly given prior reports linking obesity with elevated of C-reactive protein [67,68]. This evidence concerns the gene GPR15 and obesity due to melanocortin 4 receptor deficiency.