Among miRNAs upregulated in MM PCs, several reports demonstrated the oncogenic role of miR-221/222, a miRNA cluster acting via repression of CDKN1B (p27Kip1), BBC3 (PUMA), PTEN and CDKN1C (p57Kip2) [106,107,108]. This evidence concerns the gene BBC3 and Miyoshi myopathy.