Regorafenib (Stivarga®, Bayer), structurally similar to sorafenib, is an oral multi-kinases inhibitor with pharmacological activity against factors involved in tumor angiogenesis (such as VEGFRs), in tumor cell proliferation (such as c-KIT, RAF and RAS) and tumor microenvironment (such as PDGFRs and FGFRs). The gene discussed is KIT; the disease is neoplasm.