For example, CX3CR1 is the receptor for fractalkine, and is involved in normal B cell function and immune regulation, but has also been found to be overexpressed in B cell lymphomas and B-CLL in humans [26–28], suggesting that a similar upregulation due to RRV infection may also be associated with disease development in RM. This evidence concerns the gene CX3CR1 and B-cell chronic lymphocytic leukemia.