Although other factors are likely to have contributed to the eventual development of lymphoma in this animal, the elevation in GPC1 protein levels in CD20+ cells from LN after RRV infection at d28, and the high level detected in lymphoma-derived B cells, strongly suggests that GPC1 induction has the potential to be directly associated with development of cancers in RRV-infected RM. This evidence concerns the gene GPC1 and lymphoma.