TXNIP and disease arising from reactivation of latent virus: In regards to gammaherpesviruses, TXNIP expression has been found to be downregulated by EBV lytic infection in B cells [48, 50], and induced by transgenic expression of LMP2A in mice [51], while in the case of KSHV, latent infection of endothelial cells results in the induction of TXNIP expression [49].