Estimates for Plat vary between approximately 0.5 in in vitro infections and modelling [10, 63, 64], to 10−4in vivo, based on the frequency of intact HIV DNA in the face of ART in CD4+ T cells in the peripheral blood compartment [65, 66], and 10−3, based on total HIV DNA copies in rectal CD4+ T cells of individuals on ART [67]. Here, CD4 is linked to infection.