FYN and osteosarcoma: We then quantitatively examined temporal changes in cell area and perimeter of cells expressing either FynSensor (mCer-Fyn:myr-mVenus-F29, DNA ratio 1:2, also see Figure 3D) or the binder alone or a control construct (myr-tagged-mVenus) in the adherent osteosarcoma U2OS cells at the expression levels specified.