With the developing of sequencing technology, the mutations of several new genes, including APC, MYC, JAK1, COL11A1, LRP1B, FGF19, RB1, MUC16, and PCLO, in HCC tissues, especially in HBV‐related HCC tissues, have been discovered recently.13, 21, 22, 23 However, to date, a comprehensive understanding of the highly mutated genes, which are responsible for the development of HBV‐related HCC, is lacking. The gene discussed is MUC16; the disease is hepatocellular carcinoma.