HSPG2 and hepatocellular carcinoma: As the results shown in Figure 5A, compared with HBV‐related HCC with BCLC staging between 0 and A, the mutation frequencies of COL12A1, TERT, c5orf42, CUBN, MDN1, OBSCN, EYS, FAT2, and HSPG2 were increased in patients with BCLC staging between B and C. In addition, compared with female HBV‐related HCC patients, the mutation percentage of COL6A6 was significantly increased in male HCC patients with HBV infection (Figure 5B).