The mutation frequency and mutation status of identified highly mutated genes in all enrolled HBV‐related HCC patients are shown in Figure 2A. Among these genes, TP53, TTN, MUC16, CTNNB1, PCLO, HMCN1, GPR98, CSMD3, OBSCN, and RYR2 were top 10 highly mutated genes in enrolled HBV‐related HCC patients. The gene discussed is CSMD3; the disease is hepatocellular carcinoma.