The results show that in GC patients without H pylori infection, KLF4 expression has a strong positive rate of 51.9% in GC tissue, while in GC patients with H pylori infection, KLF4 expression has a positive rate of 27.9% in GC tissue; these results indicate that expression of KLF4 is apparently decreased in H pylori‐infected patients compared to that in patients without H pylori infection (P = .042). Here, KLF4 is linked to Helicobacter pylori infectious disease.