Similar to a large number of studies, we found that KLF4 is related to the regulation of cell differentiation and proliferation.21, 22, 23, 24, 25 Therefore, the GC cells AGS and the normal gastric epithelial cells GES‐1 were transiently transfected with the empty vector plasmid αSR and the plasmid with H pylori CagA‐wt (3.0 μg), respectively, and then the cell proliferation and migration were detected. This evidence concerns the gene KLF4 and gastric cancer.