Krüppel‐like factor 4 (KLF4) is expressed in terminally differentiated epithelial cells of the gastrointestinal tract, lungs, and several other tissues.5 The function of KLF4 is mainly to regulate cell differentiation and apoptosis.6 It has been proposed that promoter methylation is required for KLF4 inactivation in GC6; clinical trials have demonstrated that targeting specific molecules to activate KLF4 is beneficial for therapeutic intervention of advanced solid tumors.7 However, the molecular mechanisms of KLF4 need to be explored in GC. The gene discussed is KLF4; the disease is gastric cancer.