Increasing evidences revealed that there is a crosstalk between Kras mutation and T cell immune disorder in Kras mutation tumors.13, 28 Pancreatic cancer cells with oncogenic Kras mutation secrete various important molecules to affect components of the stroma, such as innate and adaptive immune cells.29, 30 These cells in turn promote and maintain tumor growth and metastasis. The gene discussed is KRAS; the disease is immune system disorder.