SERPINB3 and squamous cell carcinoma: According to previous reports, the SERPINB3 gene is expressed in mainly squamous cells, and its expression is closely related to cellular differentiation in both normal and malignant squamous cells.14, 15 To determine the potential of the SERPINB3 gene for the targeted therapy of squamous cell carcinoma, we detected the expression of the SERPINB3 gene in different cell lines (TCA8113, HeLa, MG63, L02) by Western blotting and RT‐qPCR.