Therefore, the aim of the present study was to explore the associations between rs2237895 and lipid profiles (TC, TG, LDL-C, HDL-C, Apo-A, apolipoprotein B (Apo-B)) and T2DM in Chinese to interpret the pleiotropic genetic effects of KCNQ1. The gene discussed is KCNQ1; the disease is type 2 diabetes mellitus.