NPPB and hydrops fetalis: Because both BNP/NT-proBNP and echocardiography have limitations and the guidelines recommend using them in different situations, it was still worthy of scientific research to explore the association between them Roberts et al. concluded that there was no statistical difference between the diagnostic accuracy of plasma BNP and NT-proBNP, though NT-proBNP had a longer half-life than BNP, and that the measurement of MRproANP may also be a valuable rule-out test for HF [44, 51], which is rarely measured in the current clinical practice.