As the 2016 European Society of Cardiology guidelines for HF recommend, the upper limit of normal in the nonacute setting for BNP is 35 pg/mL and for NT-proBNP it is 125 pg/mL; in the acute setting, higher values should be used (BNP, 100 pg/mL, NT-proBNP, 300 pg/mL, and mid-regional pro-A-type natriuretic peptide (MR-proANP), 120 pmol/L) [46]. This evidence concerns the gene NPPB and hydrops fetalis.