Covariance analysis (ANCOVA) revealed a significant increase in SOD (p = 0.007) and CAT (p = 0.001), as well as a significant reduction in MDA (p = 0.04) in the taurine group compared with the placebo group after adjusting for baseline variables, duration of T2DM, weight, and calorie intake changes; however, no significant difference was observed in TAC (p = 0.06). The gene discussed is SOD1; the disease is type 2 diabetes mellitus.