IL-6, VEGFA, and AHR interact to induce eosinophilic airway inflammation, mucinous metaplasia, subepithelial fibrosis, myocyte proliferation, and dendritic cell activation, leading to airway hyperresponsiveness [32–34] and angiogenesis of airway remodeling [35–38]. This evidence concerns the gene IL6 and airway hyperresponsiveness.