The top 20 genes were regarded as melanoma genes (CDKN2A, MC1R, NRAS, MITF, PTEN, TERT, POT1, BRAF, TP53, TYR, CDK4, MLANA, PMEL, IL2, ERCC2, IFNG, TNF, PTGS2, CDKN2B, TYRP1). Here, TYR is linked to melanoma.