The top 20 genes were regarded as melanoma genes (CDKN2A, MC1R, NRAS, MITF, PTEN, TERT, POT1, BRAF, TP53, TYR, CDK4, MLANA, PMEL, IL2, ERCC2, IFNG, TNF, PTGS2, CDKN2B, TYRP1). The gene discussed is BRAF; the disease is melanoma.