BRAF and neoplasm: Even though we are in the in the era of molecular characterization, sometimes BRAF testing is not available or reimbursed, but given its great negative prognostic value, in mCRC patients, a simple nomogram to predict V600EBRAF mutation in RASwt population has been developed, using gender, primary tumor location (right-sided vs left sided) and histology (mucinous vs non mucinous).