SMAD4 and colorectal carcinoma: The “conventional” pathway (70–80% of sporadic CRCs), is linked to CIN and is characterized by an early APC truncating mutation and subsequent alterations in SMAD4 and TP53 genes for the tubular adenoma (CRC BRAFwt/KRASwt/MSS) and also in KRAS gene for tubulovillous adenoma (CRC BRAFwt/KRASmt/MSS) [5, 51].