Hence, CRCs bearing non-V600 BRAF mutations constitute a distinct clinico-pathological subset, different from other BRAF mutations classes; indeed, class 2 and class 3 CRCs usually are non-mucinous, MSS, arise on the left side of younger male patients, have no peritoneal spread, lower grade at presentation and are related to a more favorable overall survival (OS) rates compared to both V600EBRAF mutants and wild-type CRCs [23, 34, 74]. This evidence concerns the gene BRAF and Marinesco-Sjogren syndrome.