To explain unresponsiveness of mCRC to BRAF inhibition, several resistance mechanisms have been identified: firstly, BRAF inhibition can induce a feedback activation of EGFR, which supports cellular proliferation; interestingly a difference in EGFR expression degree between melanoma and mCRC cells has been observed, which could partially explain the difference in clinical response to BRAF inhibition [119]. Here, BRAF is linked to melanoma.