TP53 and cervical squamous intraepithelial neoplasia: Indeed, often displaying TP53 mutation, correlated with “conventional” pathway and advanced stage but uncommon in MSI CRCs [82–84]; have a comparably high rate of CIN as BRAFwt CRCs, though with different patterns (“focal” vs “whole chromosome arms”) [82, 83] indicating the prominent CIN contribution to the progression and poor outcomes [83].