In the previous study from our lab, Liu et al. determined that the transcription factor TFAP2A promotes tumor metastasis and EMT via activating cytokeratin KRT16 transcriptionally 8, in the current study we identified TFAP2A could also activate the expression of ITPKA, which is a new mechanism for the ITPKA hyper-expression in lung adenocarcinoma. The gene discussed is ITPKA; the disease is lung adenocarcinoma.