This study suggests that exosomal TBILA (TGFβ-induced lncRNA) and AGAP2-AS1 (AGAP2 antisense RNA 1) may be novel potential biomarkers and the combination of two exosomal lncRNAs and Cyfra21-1 could improve the diagnostic accuracy for NSCLC patients. This evidence concerns the gene TBILA and non-small cell lung carcinoma.