We have previously shown that USP10 stabilises oncogenic FLT3 and targeting of USP10 leads to death of mutant FLT3-positive cells.18 Here, we validated USP10 as a DUB that stabilises SYK by showing that targeted loss of USP10 by genetic KO or KD leads to ubiquitin-mediated degradation of SYK protein in AML cells, with no effect on SYK transcription. The gene discussed is SYK; the disease is acute myeloid leukemia.