Similar effects of USP10 KO and USP7 KO on SYK protein levels were observed in wt FLT3-expressing HEL-Cas9-GFP cells, which were investigated to determine if SYK is a substrate of USP10 in both wt and mutant FLT3-expressing AML (Supplementary Fig. 5B). Here, USP7 is linked to acute myeloid leukemia.