Similar effects of USP10 KO and USP7 KO on SYK protein levels were observed in wt FLT3-expressing HEL-Cas9-GFP cells, which were investigated to determine if SYK is a substrate of USP10 in both wt and mutant FLT3-expressing AML (Supplementary Fig. 5B). The gene discussed is USP10; the disease is acute myeloid leukemia.