However, the observation that TP53, SF3B1 and RPS15 mutations remain poor risk factors in the German CLL8 trial comparing FCR vs. FC [20] and the continuing global need for chemotherapy in CLL for the foreseeable future, indicate that genomic data from the UK CLL4 trial will continue to have clinical relevance. This evidence concerns the gene TP53 and B-cell chronic lymphocytic leukemia.