In addition, TP53 mutations were associated with poor response (Fig. 3b), NOTCH1 + 3′UTR mutations were associated with death from Richter’s syndrome (Fig. 3c), whilst TP53, SF3B1, NOTCH1 + 3′UTR, KRAS and EGR2 were significantly associated with < 10 year survival (Fig. 3d). The gene discussed is NOTCH1; the disease is Richter syndrome.