First, we searched for alterations in the expression of genes of the ALDH family in the two major histopathological subtypes of NSCLC, lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC), by analyzing RNA sequencing (RNAseq) data in datasets from The Cancer Genome Atlas (TCGA) (cBioPortal) [23]. This evidence concerns the gene LDHA and non-small cell lung carcinoma.