Likewise, co-treatment with FFAs and INT-767 induced a progressive decrease of FXR expression and a slight increase of SHP, while in the non-NASH environment INT-767 induced a modest reduction of FXR mRNA and a greater increase in SHP expression compared to the FFA-treated samples (6.4 times higher compared to control). The gene discussed is NR1H4; the disease is metabolic dysfunction-associated steatohepatitis.