Plasma serine protease activity was also positively correlated with BMI (r = 0.14, p = 0.0001), HBA1c level (r = 0.255, p = 0.019; Fig. 1F–H), homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.256, p = 0.017), insulin level (r = 0.213, p = 0.048), and negatively with adiponectin concentration (r = −0.264, p = 0.014). The gene discussed is ADIPOQ; the disease is Insulin resistance.