Another study demonstrated that pre-treatment with GW4869 in RAW264.7 macrophages and wild-type mice significantly decreased release of exosomes and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and indicated that blocking exosome generation in sepsis reduces the sepsis-triggered inflammatory response which inturn improves cardiac function and survival44. The gene discussed is IL6; the disease is Sepsis.