As an explanation of the results of the present study, it should be highlighted that the dysfunctional damage at the endothelium level found in patients with periodontitis and with CHD can be determined by a specific inflammatory and immune pathway in which ET-1 modulates a response towards pathogenic bacteria of the oral biofilm which are exacerbated during the active phases of periodontal damage. This evidence concerns the gene EDN1 and periodontitis.