The median concentrations of salivary and serum ET-1 were significantly higher in the CHD patients [serum: 1.4(1.1–1.6) pg/ml; saliva 1.2 (0.9–1.6) μmol/g, p < 0.01] and in the periodontitis + CHD patients [serum: 1.7 (1.2–21.8) pg/ml; salivary 1.4(1–1.6) μmol/g, p < 0.001] respect to periodontitis and control patients. The gene discussed is EDN1; the disease is periodontitis.