APOE and Alzheimer disease: The APOE2/2 genotype was associated with a significantly lower 0.34 Alzheimer’s dementia OR compared to the relatively low odds APOE2/3 genotype (95% CI: 0.12–0.95), an extremely low 0.13 OR compared to the most common APOE3/3 genotype (95% CI: 0.05–0.36), and an exceptionally low 0.004 OR compared to the highest odds APOE4/4 genotype (95% CI: 0.001–0.014) in those neuropathologically confirmed subjects.