Second, as previously noted, since we do not have information from most of the participating brain banks’ neuropathologically misclassified cases and controls, we are not able to clarify with the more profound impact of different APOE genotypes and allelic doses on Alzheimer’s dementia ORs is solely attributable to the exclusion of neuropathologically misclassified cases and controls or also to any ascertain biases related to participation in a brain donation program. This evidence concerns the gene APOE and Alzheimer disease.