SIRT3 and hypertensive disorder: However, SIRT3 KO mice developed severe hypertension to 180 mmHg in response to low-dose AngII (0.4 mg/kg/d, 2 weeks) infusion, while AngII (0.4 mg/kg/d, 2 weeks) infusion increased SBP of WT mice to 143 mmHg as measured by carotid artery catheterization method (Fig. 5a).