MCL1 and obesity due to melanocortin 4 receptor deficiency: To explore the role of hepatocyte apoptosis in obesity-induced NASH, hepatocyte-specific Mcl1 knockout mice (referred to as Mcl1∆hep) and control littermates (Mcl1flox/flox referred to as WT) were placed on standard chow or high-fat, high-fructose, high-cholesterol (FFC) diet for 4 months (Fig. 1a).