Our previous studies uncovered that hepatocyte cell death in the FFC diet NASH model is mediated, at least in part, via signaling cascade initiated by TNF-related apoptosis-inducing ligand (TRAIL) receptor as FFC-fed mice lacking TRAIL, TRAIL receptor or caspase 8 (in hepatocytes) display attenuated liver injury and hepatocyte apoptosis16,31,32. The gene discussed is TNFSF10; the disease is metabolic dysfunction-associated steatohepatitis.