More specifically, β-TrCP1 depletion caused a significant decrease in the IC50 values of VM-26 in SK-BR3 and H1299 cells from 255.6 nM to 124.2 nM and from 94.4 nM to 58.6 nM (Fig. 7a and Fig. S7A), respectively, indicating that cancer cells are more sensitive to VM-26 treatment after β-TrCP1 depletion. The gene discussed is BTRC; the disease is cancer.