KMT2A and acute myeloid leukemia: It was observed that many upregulated genes in KMT2A-PTD AML with DNMT3A-MT were less methylated and some genes were more methylated in EOL-1 cells expressing DNMT3A-R882C mutation compared to DNMT3A-WT, indicating that DNMT3A mutations controlled the gene expression changes by both DNA methylation-dependent and -independent manner in KMT2A-PTD AML.