In addition to the upregulation of MCL-1, pathways involved in granulocytic/monocytic lineage proliferation, including HOXB2, RAB20, SOCS3, and MEIS1, were activated, and those involved in platelet activation, including PRKCA, PF4, and ITGA2B, were upregulated in KMT2A-PTD AML with DNMT3A mutations. The gene discussed is SOCS3; the disease is acute myeloid leukemia.