GSEA indicated that the gene set induced by DNMT3A-WT with KMT2A-PTD positively correlated with those of enriched in mRNA processing, RNA splicing and RNA methylation activated gene sets, and negatively correlated with those enriched in platelet activation when compared with the gene sets induced by DNMT3A mutant with KMT2A-PTD AML (Fig. 3c−f). The gene discussed is DNMT3A; the disease is acute myeloid leukemia.