In addition to the upregulation of MCL-1, pathways involved in granulocytic/monocytic lineage proliferation, including HOXB2, RAB20, SOCS3, and MEIS1, were activated, and those involved in platelet activation, including PRKCA, PF4, and ITGA2B, were upregulated in KMT2A-PTD AML with DNMT3A mutations. This evidence concerns the gene DNMT3A and acute myeloid leukemia.