N6-methyladenosine was the most established and internal modification that occurred in the mRNA which was catalyzed by a methyltransferase complex containing methyltransferase-like 3 (METTL3), RNA methyltransferase-like 1 (RNMTL1) and methyltransferase-like 1 (METTL1), were downregulated, and Wilm’s-tumor-1-associated protein (WTAP)33,39 was upregulated in KMT2A-PTD AML with DNMT3A mutations. Here, WTAP is linked to acute myeloid leukemia.