Analyses of a subset of the same microarray dataset, we found that AML with KMT2A-PTD/DNMT3A mutations enhanced the HOXB gene expression compared with KMT2A-PTD/DNMT3A-WT which was consistent with our in vitro data in EOL-1 cells expressing DNMT3A-WT/MT. Here, DNMT3A is linked to acute myeloid leukemia.