Immunoblot data showed that DNMT3A expression was downregulated in KMT2A-PTD/DNMT3A-MT AML cells; conversely, the expression of BCL2 and CDK1 was upregulated in similar cells compared to KMT2A-PTD/DNMT3A-WT AML cells (Supplemental Fig. S4). The gene discussed is CDK1; the disease is acute myeloid leukemia.