In accordance with the in vitro cooperation of DNMT3A-MT with KMT2A-PTD, we observed the transduction of DNMT3A-MT in EOL-1 cells, a KMT2A-PTD-positive leukemias cell line, augmented cell growth and clonogenicity, as well as increased self-renewal activity of the transduced-primary murine BMC-expressing Kmt2a-PTD. The gene discussed is KMT2A; the disease is leukemia.