DNMT3A and leukemia: To elucidate the functional role of DNMT3A-WT/MT in KMT2A-PTD-positive leukemia cells, we stably expressed DNMT3A-wild-type (WT), DNMT3A-R882C/H (DNMT3A-MT) and empty vector (EV) control in EOL-1 cells (Fig. 1a).