DNMT3A and acute myeloid leukemia: However, we observed that downregulation of the DNMT3A level in KMT2A-PTD/DNMT3A-MT AML primary cells with FLT3-ITD or without FLT3-ITD relative to KMT2A-PTD/DNMT3A-WT, suggesting that DNMT3A-WT/MT status had maintained DNMT3A expression rather than FLT3-ITD status.