Similarly, primary BM cells from AML patients with KMT2A-PTD/DNMT3A mutations showed higher HOXB expression compared to KMT2A-PTD/DNMT3A-WT, which indicate a critical role of HOXB in AML with KMT2A-PTD/DNMT3A-MT. Here, DNMT3A is linked to acute myeloid leukemia.