RAG1 and acute lymphoblastic leukemia: To determine whether this result was indicative of their ability to deplete B-ALL from in vivo niches, we evaluated early organ-specific changes in leukemia burden after systemic administration of endosomal TLR agonists to Eμ-ret B-ALL engrafted wild-type (wt) and RAG1−/− (lacking T, B, and NKT cells) BALB/c mice.