TLR8 and neoplasm: sEVs need TLR signaling to mediate tumor-promoting inflammation: sEVs released from lung cancer cells carry two types of miRNAs (miR-21 and miR-29a) that can bind to human TLR8 and murine TLR7, inducing the activation of NFκB signals and promoting tumor growth and metastasis by secretion of pro-inflammatory cytokines [127].