CD8A and neoplasm: Gastric cancer-derived sEVs were shown to increase tumor-associated macrophages and impaired CD8+ T cell function via IL-10 (Zhang L et al. (2019)), while glioblastoma-derived sEVs skewed the monocytes toward the M2 phenotype, inducing activation of STAT3 or phosphorylation of p70S6 kinase and ERK1/2 [114].