When associated with sEVs, TGFβ induces the transcription of mRNAs similar but not identical to those induced by TGFβ in soluble form; particularly, mesothelioma-released sEVs stimulated a strong induction of FGF2 mRNA while TGF-β treatment modestly induced FGF2 expression [43]. This evidence concerns the gene TGFB1 and mesothelioma.