It remains unclear whether the photoreceptor cells are the primary affected cells in RP associated with PRPF31, with a number of studies suggesting that the RPE is the primary affected tissue(Farkas et al., 2014; Hamieh and Nandrot, 2019; Valdés-Sánchez et al., 2019). Here, PRPF31 is linked to retinitis pigmentosa 1.