TILs are enriched in TCGA-MES glioblastomas and strongly associated with mutations in NF1 and RB1. Conversely, TILs are depleted in the TCGA-CL class, EGFR-amplified, and homozygous PTEN-deleted tumors and rare in histologies characterized by these alterations (Rutledge et al., 2013). This evidence concerns the gene EGFR and glioblastoma.